The first thing you will notice when you first open Photoshop CS6, is the new look. There is a new dark User Interface. It’s a bit of a culture shock at first, but once you get used to it, it’s really great. There are four different flavors of it and you can change them all in the preferences menu. Yes, the old familiar light interface is one of the options. I suggest giving the dark ones a go though, you might just love them. You can also press the Shift+F1 orF2 keys to cycle through the new colors.
Another thing, you might not notice at first is that the look and feel of the panels have been tightened up and now more consistent naming is used throughout.